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2023 Science@theInterface Symposium
The 2023 RNA symposium features speakers from multiple universities and institutions who are leaders in the field of RNA biology, nucleic acids therapy, origin of life, plant biology, and neuroscience. This all-day symposium also has a poster session on many areas in RNA science and social hours for in-person discussions with speakers.
Date: June 12, 2023
Location: Eckhardt Research Center, Room 161
Schedule
7:30 -8:45 am Breakfast
Morning Session: 9 am – 12:10 pm; Session Chair: Chuan He
9:00 am: Jack Szostak
9:45 am: Lynn Maquat
10:30-11 am: Break
11:00 am: Allan Drummond
11:45 am: Xinnian Dong
12:30 pm – 2:00 pm Lunch
Afternoon Session: 2:00 pm- 4:15pm; Session Chair: Tao Pan
2:00 pm Sue Ackerman
2:45 pm: Jingyi Fei
3:00 pm- 3:30 pm: Break
3:30 pm – 4:15 pm: Adrian Krainer
4:15 pm – 6:00 pm: Poster session and reception
Kindly register for the symposium here
2023 Seitz Lecture: Evangelina Nogales De La Morena| 5.19.23
Structural Insights into the regulation of the gene silencer PRC2
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator that modifies histone
H3 by trimethylation of lysine 27 (H3K27me3). Spreading of the H3K27me3 mark
ultimately results in chromatin compaction and leads to the repression of the underlying
genes. PRC2 activity is essential during embryonic development and to maintain cell
identity in adulthood, with mutations and/or misregulation of PRC2 leading to cancer.
We have studied the molecular principles underlying regulation of the core PRC2 by
cofactors and by histone modifications. Recently, it has been shown that PRC2
undergoes auto-methylation within its catalytic SET domain, which results in stimulation
of its function by an unknown mechanism. Using cryo-electron microscopy, optimized
for fragile complexes, we have been able to obtain structural information that leads to a
novel mechanism of auto-regulation by an epigenetic factor.
2022-2023 Interdisciplinary Research Seminar Schedule
All seminars will be held at noon at the Gordon Center for Integrative Science W301.
Date | Speaker | Institution |
October 18 | Marcel Van der Heijden | Erasmus MC, Rotterdam |
October 25 | Hoi-Sung Chung | NIDDK/NIH |
November 1 | Jian Ma | CMU |
November 15 | Simon Scheuring | Cornell Univ |
January 24 | Susan Golden | UCSD |
February 7 | Abbas Ourmazd | Univ Wisconsin-Milwaukee |
February 21 | Megan McClean | Univ Wisconsin-Madison |
March 21 | Jody Puglisi | Stanford Univ |
April 11 | Sri Iyer Biswas | Purdue Univ |
April 18 | Zev Gartner | UCSF |
April 25 | Mimi Shirasu-Hiza | Columbia Univ |
May 2 | Jim Hurley | UC Berkeley |
May 16
May 23 |
Feng Yue | Northwestern Univ
University of Chicago |