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2023 Science@theInterface Symposium

The 2023 RNA symposium features speakers from multiple universities and institutions who are leaders in the field of RNA biology, nucleic acids therapy, origin of life, plant biology, and neuroscience. This all-day symposium also has a poster session on many areas in RNA science and social hours for in-person discussions with speakers.

Date: June 12, 2023

Location: Eckhardt Research Center, Room 161

Schedule

7:30 -8:45 am Breakfast

Morning Session: 9 am – 12:10 pm; Session Chair: Chuan He

9:00 am: Jack Szostak

9:45 am: Lynn Maquat

10:30-11 am: Break

11:00 am: Allan Drummond

11:45 am: Xinnian Dong

12:30 pm – 2:00 pm Lunch

Afternoon Session: 2:00 pm- 4:15pm; Session Chair: Tao Pan

2:00 pm Sue Ackerman

2:45 pm: Jingyi Fei

3:00 pm- 3:30 pm: Break

3:30 pm – 4:15 pm: Adrian Krainer

4:15 pm – 6:00 pm: Poster session and reception

Kindly register for the symposium here

 

2023 Seitz Lecture: Evangelina Nogales De La Morena| 5.19.23

Structural Insights into the regulation of the gene silencer PRC2

Polycomb repressive complex 2 (PRC2) is an epigenetic regulator that modifies histone
H3 by trimethylation of lysine 27 (H3K27me3). Spreading of the H3K27me3 mark
ultimately results in chromatin compaction and leads to the repression of the underlying
genes. PRC2 activity is essential during embryonic development and to maintain cell
identity in adulthood, with mutations and/or misregulation of PRC2 leading to cancer.
We have studied the molecular principles underlying regulation of the core PRC2 by
cofactors and by histone modifications. Recently, it has been shown that PRC2
undergoes auto-methylation within its catalytic SET domain, which results in stimulation
of its function by an unknown mechanism. Using cryo-electron microscopy, optimized
for fragile complexes, we have been able to obtain structural information that leads to a
novel mechanism of auto-regulation by an epigenetic factor.

2022-2023 Interdisciplinary Research Seminar Schedule

All seminars will be held at noon at the Gordon Center for Integrative Science W301.

Date Speaker Institution
October 18 Marcel Van der Heijden Erasmus MC, Rotterdam
October 25 Hoi-Sung Chung NIDDK/NIH
November 1 Jian Ma CMU
November 15 Simon Scheuring Cornell Univ
January 24 Susan Golden UCSD
February 7 Abbas Ourmazd Univ Wisconsin-Milwaukee
February 21 Megan McClean Univ Wisconsin-Madison
March 21 Jody Puglisi Stanford Univ
April 11  Sri Iyer Biswas Purdue Univ
April 18 Zev Gartner UCSF
April 25 Mimi Shirasu-Hiza Columbia Univ
May 2 Jim Hurley UC Berkeley
May 16

May 23

Feng Yue

Elizabeth Jerison

Northwestern Univ

University of Chicago

NEWS

2023 Science@theInterface Symposium

The 2023 RNA symposium features speakers from multiple universities and institutions who are leaders in the field of RNA biology, nucleic acids...

2023 Seitz Lecture: Evangelina Nogales De La Morena| 5.19.23

Structural Insights into the regulation of the gene silencer PRC2 Polycomb repressive complex 2 (PRC2) is an epigenetic regulator that modifies...

2022-2023 Interdisciplinary Research Seminar Schedule

All seminars will be held at noon at the Gordon Center for Integrative Science W301. Date Speaker Institution October 18 Marcel Van der Heijden...

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