Spatiotemporal dynamics of the heat shock response
David Pincus PhD, University of Chicago

To maintain homeostasis amidst environmental perturbations, organisms have evolved adaptive pathways at multiple scales that sense and respond to physical and chemical changes. The heat shock response (HSR), a transcriptional program that dynamically regulates expression of molecular chaperones according to cellular demands, is among the most fundamental and highly conserved of these pathways. Despite its eponymous association with heat, elevated temperature is neither necessary nor sufficient to activate the HSR. Rather, unassembled protein complexes and bimolecular condensates activate the HSR by spatially sequestering molecular chaperones. In this seminar, I will present our recent advances in elucidating the cascade of events that initiate the HSR in budding yeast with special emphasis on the spatiotemporal dynamics of the ligands, chaperones and transcription factors that orchestrate the response.

 12:001:00 p.m.
Gordon Center for Integrative Science,
Room W301 929 East 57th Street, Chicago, IL