Program in Physical and Chemical Biology
PCBio Mentors and their Research Interests
(listed alphabetically)
Structure-function analysis of the immune system
Douglas Bishop Ph.D., Dept. Molecular Genetics and Cell Biology
Molecular biology and genetic analysis of DNA recombination
Peptide antagonists of DNA repair
Sean Crosson Ph.D., Dept. Biochemistry & Molecular Biology
Signal detection and transduction in bacteria
Aaron Dinner Ph.D, Dept. Chemistry
Signaling in the immune system
Margaret Gardel Ph.D., Dept. Physics
Biophysical behaviors of the cellular cytoskeleton
Karl Freed Ph.D, Dept. Chemistry
Protein dynamics, aggregation and folding
Benjamin Glick Ph.D., Dept. Molecular Genetics and Cell Biology
Cell biology and genetics of Golgi biogenesis
Novel methods for time-lapse fluorescence microscopy
Michael Glotzer Ph.D, Dept. Molecular Genetics and Cell Biology
Molecular control of cytokinesis
Steve A.N. Goldstein M.D.-Ph.D., Dept. Pediatrics
Ion channel structure and function
Jean Greenberg Ph.D., Dept. Molecular Genetics and Cell Biology
Genetic regulation of plant responses to bacterial pathogens
Proteomic analysis by mass spectrometry
Geoffrey Greene Ph.D., Ben May Cancer Research Institute and Dept. Biochemistry & Mol. Biol.
Molecular biology of estrogen regulated gene expression
Discovery of new chemical modulators of estrogen receptor
Robert Haselkorn Ph.D., Depts. Chemistry, Biochemistry & Mol. Biol. and Mol. Gen. and Cell Biol.
Nitrogen fixing bacteria, genomics and molecular biology
Genome scale analysis of bacteria
Chuan He Ph.D, Dept. Chemistry
DNA repair
Metal ion biosensors
Rustem Ismagilov, Ph.D, Dept. Chemistry
Microfluidic approaches to the study of complex systems
Richard B. Jones Ph.D., Ben May Department for Cancer Research
Growth factor signaling in human cells
Systems-level approaches: protein microarrays and mass spectrometry
Robert Josephs Ph.D., Dept. Molecular Genetics and Cell Biology
Advanced electron microscopies and structural analysis
New methods for electron crystallography
Bob Keenan Ph.D., Dept. Biochemistry & Molecular Biology
Structural biology and directed evolution
Fluorescent Proteins
Stephen Kent Ph.D., Depts. Chemistry and Biochemistry & Molecular Biology
Protein design by native chemical ligation
Shohei Koide Ph.D., Dept. Biochemistry & Molecular Biology
Structural biology and protein engineering
Protein-based nanomaterials
David Kovar Ph.D., Molecular Genetics and Cell Biology
Cellular coordination of actin filament assembly
Real time single actin filament imaging
Sergey Kozmin Ph.D, Dept. Chemistry
Chemical biology of natural products
Small molecule libraries to probe signaling pathways
Stephen Kron M.D.-Ph.D., Dept. Molecular Genetics and Cell Biology
Cell cycle, checkpoint and signaling pathways in yeast
Novel methods for functional biochips
Ka Yee Lee Ph.D, Dept. Chemistry
Biophysical Chemistry
Lipid-Protein Interactions
Membranes Biophysics
Manyuan Long Ph.D., Dept. Ecology and Evolution
Genome scale analysis of gene evolution and function
Marvin Makinen M.D.-Ph.D., Dept. Biochemistry & Molecular Biology
Structural biology/structural basis of enzyme function/enzyme
Kinetics/metalions in biology/electron magnetic resonance
Elizabeth McNally M.D.-Ph.D., Depts. Medicine and Human Genetics
Roles of dystrophin associated glycoproteins in muscular dystrophies
Stephen Meredith M.D.-Ph.D., Dept. Biochemistry & Molecular Biology
Proteinaggregation in disease
Dominique Missiakas Ph.D.,Dept. Microbiology
Stress signaling in bacteria
Keith Moffat Ph.D, Dept. Biochemistry & Molecular Biology
Molecular mechanisms of light-dependent signal transduction
Time-resolved X-ray crystallography
Milan Mrksich Ph.D, Dept. Chemistry
Surface Chemistries to study Cell Adhesion and Migration
Drug discovery
Piers Nash Ph.D., Ben May Department for Cancer Research
Protein-protein recognition via domain interactions
Proteomic methods for analyzing complexes
Marcelo Nobrega MD, PhD., Department of Human Genetics
Gene regulation and regulatory mutations in human diseases
James Norris Ph.D, Dept. Chemistry
Probing reactive oxygen species in human and animal cells
Using light to label molecules involved in cell biochemistry
Tao Pan Ph.D., Dept. Biochemistry & Molecular Biology
Functional genomics of tRNA; RNA folding
Joseph Piccirilli Ph.D., Depts. Chemistry and Biochemistry & Molecular Biology
Chemistry of RNA splicing and catalysis
Daphne Preuss, Ph.D., Dept. Molecular Genetics and Cell Biology
Plant fertilization and development
High throughput genomic and genetic methods
Viresh Rawal Ph.D, Dept. Chemistry
Chemical synthesis and study of bioactive natural products
Ilaria Rebay Ph.D., Ben May Department for Cancer Research
Signaling networks in animal development
Phoebe Rice Ph.D., Dept. Biochemistry & Molecular Biology
Structural biology and molecular mechanisms of mobile DNA
Ronald Rock Ph.D, Dept. Biochemistry and Molecular Biology
Single-molecule studies of myosin
Bernard Roizman Ph.D., Dept. Molecular Genetics and Cell Biology
Herpes virus virulence
Gene expression array technology
Marsha Rosner Ph.D., Ben May Department for Cancer Research
MAPK signaling in cell differentiation
Novel chemical probes of cell signaling
Norbert Scherer Ph.D., Dept. Chemistry
Novel spectroscopies and single molecule approaches
Olaf Schneewind M.D.-Ph.D., Dept. Microbiology
Bacterial virulence by Type III pilli
Proteomic analysis of virulence factors
Nancy Schwartz Ph.D., Dept. Biochemistry & Molecular Biology
Extracellular matrix function and development
Ridgway Scott Ph.D., Depts. of Computer Science and of Mathematics
protein-ligand interaction and solvation
Distributed computing, bioinformatics
Harinder Singh Ph.D., Dept. Molecular Genetics and Cell Biology
Early hematopoietic development
Discovering regulatory motifs by computational approaches
Tobin Sosnick Ph.D., Dept. Biochemistry & Molecular Biology
Peptide and RNA models for folding
Ursula Storb M.D., Dept. Molecular Genetics and Cell Biology
Somatic hypermutation and DNA repair
Wei-Jen Tang Ph.D., Ben May Department for Cancer Research
Structural biology of bacterial toxins and amyloid-beta degrading proteases
Drug discovery
Jun Yin Ph.D., Dept. Chemistry
Enzyme evolution and natural product biosynthesis