Burroughs Wellcome Fund Interfaces in Science
Cross-Disciplinary Program in Biophysical Dynamics and Biocomplexity

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Burroughs Wellcome Interfaces Program Visiting Scholars

We have been fortunate to sponsor thirteen Visiting Scholars since the beginning of our program. Each have spent at least two days on campus. They have presented an invited lecture to one of our interdisciplinary departments and also a lecture geared to our program on the second day with a luncheon attended by Fellows and the guest, giving time for informal conversation regarding research. The lectures are announced to all Physics, Chemistry and Computer Science graduate students as well as faculty.

In Autumn Quarter, 2004, Steven Dowdy from UC San Francisco, HHMI, gave two Public Lectures as part of his stay on campus as a BWF Visiting Scholar. On November 11, after a luncheon with BWF Fellows, Steve spoke on "The secret world of metabolism and cell cycle checkpoints" which was co-sponsored by the Dept of Molecular Genetics & Cell Biology. On November 12, he presented "Mad cows, prions, and TAT:  Delivery of macromolecular anticancer therapeutics" co-sponsored by the Department of Medicine, Hematology/Oncology.

We also invited two Guest Lecturers this year. In Winter Quarter, 2005, Michael Diehl, from Chemistry and Chemical Engineering, Caltech, presented the IBD Interdisciplinary Research Seminar "Engineering functional multiprotein assemblies: Exploring cooperative biomotor dynamics with single molecule sensitivity" and participated in a BWF Fellows Luncheon on February 2. In Spring Quarter another BWF Fellows Luncheon was held on June 1, with Ruedi Aebersold, Institute for Biotechnology, ETH Zurich and Institute for Systems Biology, Seattle. He presented the IBD-sponsored Frederick Seitz Lecture, "Systems biology and quantitative proteomics"

In Winter Quarter, Eytan Domany, from the Weizmann Institute, Israel, presented two lectures, both co- sponsored by the BWF: "Introduction to gene expression analysis" in the IBD Lecture Series on March 2, and "Applications of gene expression analysis to studies of cancer and differentiation" on March 3, for the Computations in Science series. During Spring Quarter, two other guests were on campus as BWF Visiting Scholars. Ron Vale, from UCSF gave two special seminars. On April 28, for a general physical science audience in the Computations in Science series, he spoke on "Dissecting the mechanisms of the kinesin motor protein using structural and single molecule approaches" and on April 29, with a more biological focus, he presented "Understanding cell morphology and division using RNAi and high resolution microscopy" at the MGCB seminar series. On May 11, Steve Quake from Caltech presented a JFI Colloquium, co-hosted by our program, speaking on "Imaging information in DNA, and fun with other polymers" and gave a talk in the BMB on May 12, "Automating biology with microfluidic large scale integration" sponsored by BWF Interfaces.

In Spring Quarter we hosted Jonathan Weissman, UCSF, April 21-22, who gave a talk entitled "An epigenetic switch: prion based protein regulation" for the MGCB seminar April 22 and presented "A birdseye view of the yeast proteome," co-hosted by the Department of Chemistry and Burroughs Wellcome Interfaces, April 21. Peter Rossky, University of Texas, Austin, visited May 27-28 and spoke at the JFI Colloquium May 27, and presented a talk, "Water at Interfaces" for the Burroughs Wellcome Interfaces program on May 28. Each was also a guest at the BWF Fellows Luncheon for Visiting Scholars. On October 16, James Spudich from Stanford School of Medicine, Biochemistry, was a special guest of BWF Interfaces and presented a lecture, "Single molecule mechanics and the myosin family of molecular motors" at the MGCB seminar series in the BSD.

Kevan Shokat, UCSF, Pharmacology, presented the BMB seminar, "Novel chemical approaches to deciphering protein kinase pathways"; the BWF luncheon talk, "Challenges in chemical biology" and the BWF Interfaces Visiting Scholar lecture, "New chemical approaches to tracing single enzyme function in biology."  William A. Eaton, Laboratory of Chemical Physics, NIH, gave the Chemistry Harkins Lecture, "Dynamics and the cure of sickle cell disease" and spoke on "Probing the free energy surface for protein folding with single molecule fluorescence spectroscopy" at the BWF Visiting Scholar seminar. Ann McDermott, Department of Chemistry, Columbia University presented the joint Chemistry/Institute for Biophysical Dynamics colloquium, "A dynamical view of enzymes: Studies of triosephosphate isomerase by NMR and other methods" and presented the BWF Visiting Scholar talk "Solid state NMR studies of membrane proteins involved in bioenergetics" and participated enthusiastically in the BWF luncheon where fellows had the opportunity to discuss science and the academic environment.

Nobelists Steven Chu of Stanford University and Erwin Neher of the Max Planck Institute for Biophysical Chemistry, Goettingen, visited in Spring Quarter. Steven Chu presented three lectures: "Watching enzymes do their thing, one molecule at a time" at the MGCB symposium; a BWF lunchtime informal talk on "Doing something new in science" to an audience limited to graduate students from both PSD and BSD; and the Physics Colloquium on "What can biology do for physics?"  Erwin Neher presented a talk for the BWF co-sponsored Biophysical Discussions class, "Recording and analysis techniques for studying rapid secretory responses" and a NPP and Cmte. on Cell Physiology seminar, the 2001 A. J. Carlson Lecture, on "Ca++ signals controlling neurotransmitter release and short term synaptic plasticity."

Manfred Lindau, Applied and Engineering Physics, Cornell University, participated in the BWF Luncheon and gave the Biophysical Discussions talk "Tethering and exocytosis of single vesicles" in late May.

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