Burroughs Wellcome Fund Interfaces in Science
Cross-Disciplinary Program in Biophysical Dynamics and Biocomplexity

BWF Homepage Note To Faculty Visiting Scholars
Requirements & Resources Fellows and Mentors Biophysical Discussions
Guidelines for Application Administration Other Courses
Further Description Presentations by Fellows  

Other Course Requirements

In addition to attendance at the Spring Quarter Biophysical Discussions course, to fulfill the requirements of the program, BWF fellows must take one additional course during their first year of fellowship. They can take any course approved by the co-directors; it may be for pass/fail, taking a course for grade is not required. Other courses than these suggested below are possible, pending approval from program co-directors.

Courses "created" as a result of the BW program are highlighted with asterisks.


**CMSC 37701-1 Topics in Bioinformatics: Digital Structural Biophysics
Instructor: A. Fernández
The course is aimed at exploring the digital nature of structure-encoded signals for the interactions of biomolecules, including nucleic acids and proteins. One primary interest is to provide the biophysical fundamentals for a massively parallel interrogation of biological objects at the molecular scale, implementing an information-theoretic approach. The implications of the discrete interactive signaling for structural genomics and proteomics will be emphasized.

BIOS 26400 Intro to Bioinformatics PQ: BIOS 20182 or 20192, or MATH 15100, or Instructor: W. Li. Consent of Instructor.
This course introduces the concepts, purpose, tools, skills, and resources of bioinformatics. It includes a description of GenBank and other sequence databases; genetic and physical mapping databases; and structure databases. It also explains definitions such as homology, similarity, and gene families. Other topics include the basic principles and computational skills of comparative and phylogenetic analyses of DNA and protein sequence data; computer skills in data base searching and information retrieval; predictive methods using DNA sequences; predictive methods using protein sequences; and comparative genomics. Finally, cutting-edge developments such as DNA chips and other information technologies are discussed.

**PHYS 491 Biological Physics
Instructor: Philippe Cluzel
We will investigate “What are the physical properties that make living systems evolvable?” through the reading of seminal research papers, and we will consider important questions in Biology from the perspective of the physical sciences. Students will be asked to give a very short presentation (~ 20 min) of a selected research paper and the class will then discuss the papers which the whole class will be expected to read before attending class [this will constitute the work for this course].

This course will not necessitate any prerequisite in Biology yet one class will be entirely devoted to an introduction to biotechnology.

ORGB 342 Biological Fluid Mechanics
See catalog for prerequisites or contact instructor
Instructor: M. LaBarbera

BCMB 323 Macromolecular Function
See catalog for prerequisites or contact instructor
Instructors: S. Kent, K. Moffat

BCMB 310 Fundamentals of Molecular Biology
See catalog for prerequisites or contact instructor
Instructors: U. Storb, J. Staley

MGCB 317 Advanced Cell Biology
See catalog for prerequisites or contact instructor
Instructors: G. Lamppa, P. Mueller

May be of interest:

MOLM 167-30001 Section 01 The Making of a Pancreas
Prerequisites: None
Location: Billings Hospital H103
Louis H. Philipson and Julian Solway, Course Directors
This course will survey the several knowledge areas that would be required to generate and implant a biological artificial endocrine pancreas, including glucose regulation and diabetes, insulin synthesis and action, stem cell and beta cell biology, microvascular growth, tissue engineering, and immune protection. Sessions will be held weekly on Wednesday evenings from 5:30-7:30 pm, and dinner will be provided. Students will write a final paper.


Attendance Required

**Biophysical Discussions (CPHY 350 Topics in Biophysics): Nucleic Acids
S. Kron, N. Scherer, Course Directors
Note: Attendance is a REQUIREMENT, though taking the course for credit is not a requirement. (This course can only be taken as pass/fail.) The schedule of talks by PSD and BSD faculty will be distributed at the first meeting.

**CHEM 368 Advanced Computational Chemistry and Biology
Instructor: K. Freed
The course introduces students to numerical analysis, molecular simulations involving molecular mechanics, Monte Carlo, and molecular dynamics methods, and quantum chemical calculations of electronic structure. Applications to chemical and biological systems are tailored to students’ backgrounds and interests.

CHEM 325 Bioorganic Chemistry
Instructor: J. Piccirilli.
A goal of this course is to relate chemical phenomena with biological activities. The course covers two main areas: (1) chemical modifications of biological macromolecules and their potential effects; and (2) the application of spectroscopic methods to elucidate the structure and dynamics of biologically relevant molecules.

BCMB 320 Designer Proteins and Peptides
Instructor: S. Meredith
This graduate level course will deal with the design, synthesis, and characterization of novel non-natural proteins and peptides. Some specific topics included are the following: Peptide models of transmembrane domains, membrane fusion and membrane binding proteins, apolipoproteins, and peptide hormones. Side chain modified peptides and proteins, peptide backbone modified peptides, covalent lipid-peptide and nucleotide-peptide adducts, peptide block copolymers, e.g., PEG-peptides, synthetic supersecondary structures, including 4- and 6-helix bundles, synthetic bab structures, and template assisted folding of b-sheet structures. Readings will consist entirely of journal articles.

MGCB 343 Electron Microscopy
Instructor: R. Josephs. Consent of Instructor.
Teaches students how to operate a transmission electron microscope and how to take high-resolution micrographs, learning both classical and advanced techniques.

CABI 312 Signal Transduction and Cell Cycle Regulation
Instructor: Staff, W. Du
Topics include receptor ligands, receptor tyrosine kinases and phosphatases, G protein coupled receptors, signalling pathways, cytoplasmic protein kinases and phosphatases, receptor-nucleus signalling, nuclear proto-oncogenes, cell growth suppression, tumor suppressors, regulation of cell cycle progression, modulation of cell cycle progression and apoptosis.

CABI 313 Frontiers in Cancer Research
Instructor: C. Rinker-Schaeffer
A lecture-discussion course on selected topics in cancer biology that vary from year to year but may include such subjects as DNA-mediated gene transfer, cancer.

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