Burroughs Wellcome Fund Interfaces in Science
Cross-Disciplinary Program in Biophysical Dynamics and Biocomplexity

 
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Burroughs Wellcome Interfaces Weekly Seminar Series - Presentations by Fellows
Attended by Fellows, Co-Directors and Advisory Committee Liaison

AUTUMN 2006

  • November 15: Michael Baxa, Physics, "Conformational fluctuations in biological systems: Knowing where you're going"
  • November 8: Matthew Runyon, Chemistry, "Using chemistry and microfluidics to understand the spatiotemporal dynamics of initiation and propagation in the complex network of hemostasis"
  • November 1: Syed Rizvi, Chemistry, "AuCl catalyzed synthesis of platensimycin analogs"
  • October 25: BWF Fellows Luncheon with Nobel Laureate, Ahmed Zewail, California Institute of Technology, who presented the Chemistry Department Harkins Lecture "Exploring the Fourth Dimension of Chemistry and Biology"
  • October 25: Mridu Saikia, Chemistry, "Toward detection and quantitation of RNA modification"
  • October 18: Jelena Pesic, Chemistry, "Single molecule studies of conformational change in photoactive yellow protein"
  • October 11: Erica Duguid, Chemistry, "Structures of DNA binding proteins"
  • October 4: Maria Ratajczak, Physics, "Cholesterol-lipid complexes probed in red blood cells"
  • September 27:  Leandro Cortes, Computer Science "What is that vesicle doing?"

SPRING 2006

  • May 24:   Erica Duguid, Chemistry, "Studying the interaction of O6-alkylguanine-
    DNA-Alkytransferase with DNA"
  • BWF Visiting Scholar – Stephen Lippard, Noyes Professor of Chemistry, MIT 
    Public Lectures:
  • May 23:  "Chemical and biological studies of platinum anticancer drugs" Co-sponsors: Institute for Biophysical Dynamics & Burroughs Wellcome Fund Interfaces Program
  • May 22:  "Probing the biological chemistry of mobile zinc and nitric" Lee Lecture, Department of Chemistry
  • May 17:   Dan Siegal-Gaskins, Physics, "Studying genetic network regulation with RNA probe
  • May 10:   Maria Ratajczak, Physics, "Correlation of partial immiscibility (domain formation) with cholesterol activity in red blood cell membranes"
  • May 3:     Mridu Saikia, Chemistry, "Toward microarray detection and quantitation
    of RNA modifications"
  • April 26:  Dedication of Gordon Center for Integrative Science (CIS)
  • April 19:  Jelena Pesic, Chemistry, "Photoactivated processes in single proteins"
  • April 12:  Syed Rizvi, Chemistry, "The structure-activity relationship of the bistramide A : actin complex"
  • April 5:    Shannon Stewman, Chemistry, "Pollen tube guidance: eukaryotic chemotaxis from the top down" 

WINTER 2006

  • March 8: Leandro Cortes, Computer Science, "Labeling, modeling and detecting vesicles"
  • March 1: Biophysical Society Meeting Review:Jelena Pesic, Xiaohui Qu, Maria Ratajczak, Shannon Stewman
  • February 15: Michael Baxa, Physics, "Conformational fluctuations modeled using replica exchange Langevin dynamics and hydrogen exchange"
  • February 8: Matt Runyon, Chemistry, "Using chemistry and microfluidics to understand the complex network of blood clotting "
  • February 1: Xiaohui Qu, Physics, "Non-equilibrium single-molecule measurement of RNA dynamics "
  • January 25: David Kendall, Chemistry, "Multi-scale simulation for protein structure prediction and dynamics "
  • January 18: Dan Siegal-Gaskins, Physics, "Real-time dynamics of genetic networks "
  • January 11: Jing Su, Chemistry, "Profiling caspase activation during apoptosis: A label-free approach "
  • January 4: Peng Chen, Chemistry, "Redox switch: A new view of MgrA, the major virulence regulator in S. aureus "

AUTUMN 2005

  • December 7: Maria Ratajczak, Chemistry, "Probing cholesterol/lipid complexes using ITC "
  • November 30: Jelena Janjic, Chemistry, "Using Saccharomyces cerevisiae to determine the biological target of Leucascandolide A "
  • November 16: Erica Duguid, Physics, "Studying the interaction of O6-alkylguanine-DNA-alkyltransferase with DNA "

  • November 15: George Church, Dept of Genetics, Harvard Medical School , “Synthesizing and sequencing genomes” Institute for Biophysical Dynamics Tuesday Lecture Series

    Group 10 applicants selected are:
    Michael Baxa, Physics, " Conformational fluctuations modeled using replica exchange Langevin dynamics and hydrogen exchange "
    Leandro Cortes Martinez, Computer Science, "Vesicle movement between actin filaments and the surface membrane "
    Jelena Pesic, Chemistry, "Conformational fluctuations in long range electron transfer reactions in single heme proteins "
    Syed Rizvi, Chemistry, "Biochemical characterization of the binding of Bistramide A to actin: synthesis of simplified analogs "
    Mridusmita Saikia, Chemistry, "Studies of RNA modifications on the genomic scale "
    Shannon Stewman, Chemistry, "Mechanisms of selectivity during plant mate choice "

  • November 9: Presentations by Group 10 applicants

  • November 8: BWF Fellows Luncheon with Eric Siggia, Center for Studies in Physics & Biology, Rockefeller University , who presented the IBD seminar series lecture "Fluctuations and the cell cycle in budding yeast "

  • November 2: Presentations by Group 10 applicants
  • October 26: Presentations by Group 10 applicants
  • October 19: Matt Runyon, Chemistry, "Blood and microfluidics: Testing predictions from a model system and understanding the role of threshold in healthy hemostasis "
  • October 12: Xiaohui Qu, Physics, "Non-equilibrium single-molecule FRET measurement of RNA conformational dynamics "
  • October 5: David Kendall, Chemistry, "Theory for single layer (beta)-sheets "

SPRING 2005

  • June 1: BWF Fellows Luncheon with Ruedi Aebersold, Institute for Biotechnology, ETH Zurich and Institute for Systems Biology, Seattle, who presented the IBD-sponsored Frederick Seitz Lecture, "Systems biology and quantitative proteomics"

  • May 25: Justin Jureller, Chemistry, "Studying vesicular transport dynamics with spatio-temporal image correlation spectroscopy"
  • May 18: Spencer Roach, Chemistry, "Microfluidic surface chemistry and protein crystallization"
  • May 11: Erica Duguid, Chemistry, "Studying the interaction of O6-alkylguanine-DNA-alkyltransferase with DNA"
  • May 4 - Presentations by Applicants for Group 9 Selected was:
    Dan Siegal, Physics, "A real-time study of gene networks using RNA as a reporter system"
  • April 20: Matt Runyon, Chemistry, "Human blood and microfluidics: Testing predictions from a model system and understanding the role of threshold in healthy hemostasis"
  • April 13: Maria Ratajczak, Physics, "Cholesterol-lipids interactions"

  • April 6: Bill Degrado, Biochemistry and Biophysics at UPenn, "Design of polymeric and small-molecule mimics of alpha-helices"

  • March 30: Jing Su, Chemistry, "Profiling caspase activation in apoptotic cells with mass spectrometry "

WINTER 2005

  • March 2: Xiaohui Qu, Chemistry, "Single molecule study of RNase P RNA"
  • February 23: David Kendall, Chemistry, "Studying protein binding using small molecule probes"

  • February 2: BWF Fellows Luncheon with Michael Diehl, Chemistry and Chemical Engineering, Caltech, who presented the IBD Interdisciplinary Research Seminar "Engineering functional multiprotein assemblies: Exploring cooperative biomotor dynamics with single molecule sensitivity" on Tuesday, February 1

  • January 26: Jelena Janjik, Chemistry, "Using Saccharomyces cerevisiae to determine the mode of action of Leucascandrolide A"
  • January 19: Peng Chen, Chemistry, "Identifying a new multidrug resistant regulator MgrA in Staphylococcus aureus"
  • January 12: Tanya Baker, Physics, "Spontaneous pattern formation in the visual cortex"

AUTUMN 2004

  • December 1: Justin Jureller, Chemistry, "Image correlation analysis of insulin vesicle transport"
  • November 24: Thanksgiving Break
  • November 17: Spencer Roach, Chemistry, "Protein crystallization and surface chemistry in microfluidics"

  • BWF Visiting Scholar Steven Dowdy, UC San Francisco, HHMI - Public Lectures
    November 12:
    "Mad cows, prions, and TAT: Delivery of macromolecular anticancer therapeutics"
    Co-sponsored by Department of Medicine, Hematology/Oncology
    November 11: "The secret world of metabolism and cell cycle checkpoints"
    Co-sponsored by Dept of Molecular Genetics & Cell Biology

  • October 27 and November 3: Presentations by Applicants for Group 8 - Selected were:
    Erica Duguid, Chemistry, "Studying the interaction of human O6-alkylguanine-DNA-alkyltransferase with DNA through crystallization"
    Maria Ratajczak, Physics, "Cholesterol traffic, or, How does plasma membrane cholesterol regulate cholesterol homeostasis?"
    Matt Runyon, Chemistry, "Using minimal chemical models and microfluidics to understand threshold response and sensitivity to flow in human hemostasis"
    Jing Su, Chemistry, "Profiling caspase activities in apoptotic pathways with Lab-on-a-Chip"

  • October 20: Alexandre Statsiouk, Chemistry, "Synthesis and biological properties of Bistramide A"
  • October 13: Young-Sam Lee, Chemistry, "Chemical approaches toward analysis and control of focal adhesion dynamics"
  • October 6: Jason Wyman, Physics, "Microencapsulation of islets via selective withdrawal to achieve immunoisolation"

SPRING 2004

  • BWF Visiting Scholar - Steve Quake, Cal Tech - Public Lectures
    May 12:
    "Automating biology with microfluidic large scale integration"
    Co-sponsored with Department of Biochemistry & Molecular Biology
    May 11: "Imaging information in DNA, and fun with other polymers"
    Co-sponsored with James Franck Institute

  • May 5: Presentations by Applicants Group 7 - Selected were:
    David Kendall, Chemistry, "Exploring protein-ligand association using small molecule probes"
    Xiaohui Qu, Physics, "Dynamic properties of individual RNA molecules"

  • BWF Visiting Scholar - Ron Vale, UCSF - Public Lectures
    April 29:
    "Understanding cell morphology and division using RNAi and high resolution microscopy"
    Co-sponsored with Department of Molecular Genetics & Cell Biology
    April 28: "Dissecting the mechanism of the kinesin motor protein using structural and single molecule approaches"
    Co-sponsored with Computations in Science

  • April 21: Abhishek Jha, Chemistry, "Conformational preference and nearest neighbor effects in the unfolded state"
  • April 14: Young-Sam Lee, Chemistry, "Regulating protein-protein Interactions using small molecules"
  • April 7: Jelena Janjic, Chemistry, "Using Saccharomyces cerevisiae to determine the mode of action of Leucascandrolide A"
  • March 31: Peng Chen, Chemistry, "Probing the functional role of the multidrug resistant regulatory protein BmrR"

WINTER 2004

  • BWF Visiting Scholar - Eytan Domany, Weizmann Institute - Public Lectures
    March 3:
    "Applications of gene expression analysis to studies of cancer and differentiation"
    Computations in Science Seminar - Co-sponsored by BWF
    March 2: "Introduction to gene expression analysis"
    Co-sponsored by Institute for Biophysical Dynamics and Computations in Science

  • February 18: Spencer Roach, Chemistry, "High-resolution, high-throughput crystallization of biological macromolecules in microfluidic devices"
  • February 11: Jing Liu, Computer Science, "Identification of genes and transcriptional regulatory element by unsupervised learning"
  • February 4: Justin Jureller, Chemistry, "Visualizing sub-cellular transport dynamics with multiphoton microscopic techniques"
  • January 28: Tanya Baker, Physics, "Separable cortical maps underlie population responses to complex visual stimuli"
  • January 27: Jason Wyman, Physics, "Microencapsulation of islets via selective withdrawal to achieve immunoisolation" IBD Seminar presentation
  • January 14: Jason Ming Zhao, Physics, "Update on photoactive yellow protein"

AUTUMN 2003

  • December 3-5: BWF Interfaces in Science Fellows' Retreat, Coronado Island, CA
  • November 12: Abhishek Jha, Chemistry, "Long term dynamics of a peptide"
  • October 29: Presentations by Applicants Group 6 - Selected were:
    Jelena Janjic, Chemistry, "Using Saccharomyces cerevisiae to determine the mode of action of Leucascandrolide A"
    Peng Chen, Chemistry, "Probing the functional role of the multidrug resistant regulatory protein BmrR"

  • BWF Visiting Scholar - James Spudich, Biochemistry, Stanford University School of Medicine - Public Lecture
    October 16:
    "Single molecule mechanics and the myosin family of molecular motors"
    Co-sponsored by Department of Molecular Genetics & Cell Biology

  • October 15: Richard Baxter, Chemistry, "Ubiquinone 2: the 'proximal' site strikes back"
  • October 8: Young-Sam Lee, Chemistry, "Regulating protein-protein interactions using small molecules"

AUTUMN 2002

  • November 20: Interdivisional Research Building Science Symposium and Groundbreaking
  • November 13: Matthias Möbius, Physics
    "Imaging granular fluid interactions with MRI"
  • November 6: Abhishek Jha, Chemistry
    "Long time dynamics of peptides"
  • October 30: Jason Ming Zhao, Physics
    "Mechanical study of bacterial flagella"
  • October 23: Richard Baxter, Chemistry
    "Time-resolved crystallography of the photosynthetic reaction center"
  • October 16: Alexandre Statsiouk, Chemistry
    "Small molecule regulation of protein kinase C superfamily"

SPRING 2002

  • May 1: Muhammad Zaman, Chemistry
    "Crosslinks, entropy and protein association"
  • April 24: Dal-Hee Min, Chemistry
    "Selective immobilization of proteins to SAMs"
  • April 17: Wendy Ryan, Chemistry
    "Can we learn about protein dynamics from gas phase studies of its chromophore?"
  • April 10 Guohui Wu, Chemistry
    "Study of the interaction of poloxamer p188 and lipid monolayers"
  • April 3: Richard Baxter, Chemistry
    "Towards time-resolved x-ray crystallography of the bacterial reaction center"
  • March 27: Liping Tong, Statistics
    "Map assembly for a new optical mapping method"

WINTER 2002

  • March 13: Zheng Xie, Chemistry
    "Towards the folding of a 255-nucleotide P RNA by single molecule method"
  • March 6: Jongwoo Song, Statistics
    "Statistical methods for gene expression data"
  • February 20: Alexei V. Korennykh, Chemistry
    "Quantitative study of protein-RNA interactions using protein toxin restrictocin"

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